Narative Review: Factors Influencing Medication Compliance of Hypertension Patients
DOI:
https://doi.org/10.47134/phms.v3i2.595Keywords:
Hypertension, Medication Adherence, Family Support, Motivation To Seek Treatment, Role Of Health WorkersAbstract
Hypertension is a chronic disease that requires long-term therapy to reduce the risk of cardiovascular complications, stroke, and kidney disorders. The success of antihypertensive therapy is largely determined by patient compliance in taking medication) (however, various reports indicate that compliance rates remain suboptimal. This narrative review aims to summarize recent evidence regarding factors influencing medication adherence among patients with hypertension. A systematic literature search was conducted in national and international journals published between 2020 and 2025, using predefined inclusion and exclusion criteria. The initial search identified 72 articles, of which 25 articles met the eligibility criteria and were included in the final thematic synthesis. The findings indicate that medication compliance is influenced by internal factors (knowledge, motivation, and self-efficacy) and external factors (family support, the role of health workers, perception of illness, and sociodemographic characteristics). Among these factors, treatment motivation and family support were consistently reported as the most dominant determinants of adherence. In conclusion, improving medication compliance in hypertensive patients requires a comprehensive approach that integrates continuous patient education, strengthening the role of health workers, and active family involvement in the treatment process.
References
Abdulloh, AAG, & Veriyallia, V. (2025). Motivation Level Sufferer Hypertension and Its Relationship with Compliance Taking Medication. Journal of Nursing Innovation, 4 (1), 14-19
Akri, YJ, & Puspitasari, D. (2025). The Role Of Pharmacist Intervention In Medication Compliance In Hypertension Patients: A Systematic Review. ASSYIFA: Jurnal Health Sciences, 3 (2), 145-152. DOI: https://doi.org/10.62085/ajk.v3i2.152
Alsofyani, M. A., Aloufi, A. O., Al-Qhtani, N. S., Bamansour, S. O., & Almathkori, R. S. (2022). Factors related to treatment adherence among hypertensive patients: A cross-sectional study in primary healthcare centers in Taif city. Journal of Family and Community Medicine, 29 (3), 181-188. DOI: https://doi.org/10.4103/jfcm.jfcm_153_22
Anjalina, AP, & Noor, MA (2024). Relationship Family Support with Compliance Consumption Taking Antihypertensive Medication. Journal Nursing Healthy Culture, 2 (1), 40-44.
Apsari, DP, Wibawa, IGNMS, & Maharjana, IBN (2021). Relationship Family Support and the Role of Pharmaceutical Workers to Compliance Taking Antihypertensive Medications: Indonesia. Journal Scientific Medicine, 7 (1).
Carey, R. M., Moran, A. E., & Whelton, P. K. (2022). Treatment of hypertension: a review. Jama, 328 (18), 1849-1861. DOI: https://doi.org/10.1001/jama.2022.19590
Darmirani, Y., & Dalimunthe, A. (2023). The impact of pharmaceutical care implementation on the incidence of drug-related problems and clinical outcome of hypertension patients at Puskesmas Lubuk Pakam in 2021. MPI (Media Pharmaceutica Indonesiana), 5 (1), 20-27. DOI: https://doi.org/10.24123/mpi.v5i1.5609
Ernawati, A. (2022). Media promosi kesehatan untuk meningkatkan pengetahuan ibu tentang stunting. Jurnal Litbang: Media Informasi Penelitian, Pengembangan Dan IPTEK, 18 (2), 139-152. DOI: https://doi.org/10.33658/jl.v18i2.324
Ernawati, I., Fandinata, SS, & Permatasari, SN (2020). Book reference: compliance consumption drug patient hypertension: measurement and methods increase compliance Graniti Publisher.
Fadhilah, SN (2020). Relationship support family with compliance drink medication for patients hypertension in the work area Community Health Center Pamarican Regency Ciamis 2020
Fauzi, R., Efendi, R., & Mustakim, M. (2020). Management Program Disease Hypertension Community Based with Approach Family in the Village Pondok Jaya, South Tangerang. Wikrama Parahita: Journal Community Service, 4 (2), 69-74. DOI: https://doi.org/10.30656/jpmwp.v4i2.1931
Febyanti, AV (2022). Relationship Motivation With Compliance Taking Medication in Patients Hypertension in Community Health Center Sumbersari (Doctoral dissertation, Dr. SOEBANDI University).
Guo, A., Jin, H., Mao, J., Zhu, W., Zhou, Y., Ge, X., & Yu, D. (2023). Impact of health literacy and social support on medication adherence in patients with hypertension: a cross-sectional community-based study. BMC Cardiovascular Disorders, 23 (1), 93. DOI: https://doi.org/10.1186/s12872-023-03117-x
Hamrahian, S. M., Maarouf, O. H., & Fülöp, T. (2022). A critical review of medication adherence in hypertension: barriers and facilitators clinicians should consider. Patient Preference and Adherence, 2749-2757. DOI: https://doi.org/10.2147/PPA.S368784
Handayani, SE, Warnida, H., & Sentat, T. (2022). The Influence Support Family to Compliance Taking Patient Medication Hypertension at Muara Wis. Community Health Center. Journal Scientific Manuntung: Pharmaceutical Science and Health, 8 (2), 226-233. DOI: https://doi.org/10.51352/jim.v8i2.527
Juniarti, B., Setyani, FAR, & Amigo, TAE (2023). Level of Knowledge With Compliance Taking Medication in Hypertension Patients. Cendekia Medika: Journal of Al-Maarif Baturaja Health College, 8 (1), 43-53. DOI: https://doi.org/10.52235/cendekiamedika.v8i1.205
Listiana, D., Effendi, S., & Saputra, YE (2020). Factors related to with compliance sufferers hypertension in undergo treatment at the Karang Dapo Community Health Center, Muratara Regency. Journal of Nursing and Public Health, 8 (1), 11-2 DOI: https://doi.org/10.37676/jnph.v8i1.1005
Madarina, Hanum, Noviyanti. 2022. Factors Associated with Non-Compliance Control Hypertension Sufferers. Muhammadiyah Lhokseumawe Health Information System
Mahardika, Adyani. 2023. Motivation client with compliance drink medication for patients Hypertension. National Development University.
Ristiani, K., Zega, N., Sunusi, F., & Pakpahan, M. (2023). Factors affecting hypertension treatment compliance in Cirebon. Enfermería Clínica, 33, S7-S11. DOI: https://doi.org/10.1016/j.enfcli.2023.01.002
Safitri, EM, Irianto, SE, Rahayu, D., & Setiaji, B. (2024). Factors Influencing Compliance Hypertension Patients Undergoing Treatment in the Regency West Coast 2023. J-CEKI: Journal Scholar Scientific, 3 (5), 4358-4377.
Safitri, SN, Saputra, YD, & Andanalusia, M. (2025). Compliance Level Use of Antihypertensive Drugs in Patients Hypertension at the Community Health Center Gunungsari. Sci-tech Journal, 4 (2), 133-143
Suhat, S., Suwandono, A., Adi, M. S., Nugroho, K., Widjanarko, B., & Wahyuni, C. U. (2022). Relationship of health belief model with medication adherence and risk factor prevention in hypertension patients in Cimahi City, Indonesia.
Susanto, A., & Purwantingrum, H. (2022). Analysis knowledge, support family, and roles power health with sufferers hypertension obedience drink drug antihypertensive. Journal Health Management of Dr. Soetomo Hospital Foundation, 8 (2), 275-286. DOI: https://doi.org/10.29241/jmk.v8i2.1022
WHO, 2023, data on Hypertension, accessed on May 11, 2023, at 6:50 a.m. WIB. Via the link https://www.who.int/health-topics/hypertension
Yacob, R., Ilham, R., & Syamsuddin, F. (2023). The Relationship Between Medication Compliance and Decline Blood Pressure in Patients Hypertension Prolanis Program In the Tapa Community Health Center Work Area. Thermometer: Journal Scientific Health and Medical Sciences, 1 (2), 58-67 DOI: https://doi.org/10.55606/termometer.v1i2.1297
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