Comparison of Total Leukocytes in Conventional Smokers and E-Smokers in Students of the Faculty of Medicine, University of Muhammadiyah North Sumatra

Authors

  • Putri Ricka Amelia Barus Universitas Muhammadiyah Sumatera Utara
  • Fani Ade Irma Universitas Muhammadiyah Sumatera Utara

DOI:

https://doi.org/10.47134/phms.v3i1.527

Keywords:

Leukocytes, Conventional Cigarettes, E-Cigarettes

Abstract

Smoking remains a widespread habit in Indonesia, particularly in Medan, where the prevalence of daily smokers reaches 55.2%, exceeding the national average of 54% in 2016. Despite awareness of the health risks associated with tobacco, many individuals continue smoking and some have shifted to e-cigarettes as an alternative. However, e-cigarettes are also known to have harmful effects on the body, including potential changes in leukocyte count. This study aimed to compare the total leukocyte count between conventional cigarette users and e-cigarette users. It employed an analytical observational approach with a cross-sectional design involving 60 respondents selected through purposive sampling based on inclusion and exclusion criteria. The results showed that most respondents had smoked for 1–5 years. Conventional cigarette users typically smoked 1–5 cigarettes per day, while e-cigarette users consumed 1–2 ml of liquid daily. The Mann-Whitney test produced a significance value of 0.525 (>0.05), indicating no significant difference in the total leukocyte count between conventional and e-cigarette users among medical students at the University of Muhammadiyah North Sumatra.

References

Al-Temimi, S. Q. (2017). Hematological changes in active smokers: A comparative study among different age groups (20–49 years). Iraqi Journal of Science for Radiation.

Amalia, D. (2019). Comparison of hemoglobin levels using the Sahli method in active and passive smokers in Awunio Village, South Konawe Regency. Journal of MediLab Mandala Waluya, 3, 121–132.

Ardina, R., & Nada, S. (2019). The Effect of Heavy Smoking on the Number of Leukocytes and Types of Leukocytes in Men of Productive Age in Tanjung Pinang Village, Palangka Raya City. Borneo Journal of Medical Laboratory Technology, 1(2), 34–40. DOI: https://doi.org/10.33084/bjmlt.v1i2.708

Bakhri, S. (2018). Analysis of the number of leukocytes and types of leukocytes in individuals who sleep with the lights on and those who are turned off. Journal of Media Health Analysts, 1(1), 83–91. https://doi.org/10.32382/mak.v1i1.176 DOI: https://doi.org/10.32382/mak.v1i1.176

Basic Health Research 2018. (2018). Health Research and Development Agency, Ministry of Health of the Republic of Indonesia.

Faruq, Z. H. (2018). Lysis blood analysis of platelet values using the electrical impedance method. 2(1), 11–13.

Jiang, H. (2025). Association between leukocyte-derived composite indices and premature coronary artery disease: a cross-sectional study. BMC Cardiovascular Disorders, 25(1), ISSN 1471-2261, https://doi.org/10.1186/s12872-025-05268-5 DOI: https://doi.org/10.1186/s12872-025-05268-5

Junaidin, & Kambu. (2020). The relationship between cigarette use and the number of leukocytes in active cigarette users. Journal of Health Innovation, 2(1), 16–20.

Nursidika, P., Permana, E. V, & Sustrianti. (2019). Changes in the number and type of leukocytes in e-cigarette users. 7(3), 94–101.

Rohmani, A., Yazid, N., & Rahmawati, A. A. (2018). E-cigarettes and conventional cigarettes damage the lung alveolus. Proceedings of the Unimus National Seminar, 27–32. http://prosiding.unimus.ac.id/index.php/semnas/article/view/21/13

Sanders, P. (2020). Comparison of leukocyte counts in tuberculosis patients before and after intensive phase anti-tuberculosis drug treatment. Journal of Eagle Health, 10(2), 84–94. http://ojs.rajawali.ac.id/index.php/JKR/article/view/61

Septiani, R. (2022). The relationship between smoking length and smoking frequency with hemoglobin (Hb) levels in active smokers. Babul Ilmi: Scientific Journal of Multi Health Sciences, 14(1), 30–40. DOI: https://doi.org/10.36729/bi.v14i1.809

Sirih, G. E., Engka, J. N., & Mardownload, S. M. (2017). The Relationship between Smoking and Leukocyte Levels in Chronic Smokers. Journal of E-Biomedicine, 5(2). https://doi.org/10.35790/ebm.5.2.2017.18481 DOI: https://doi.org/10.35790/ebm.5.2.2017.18481

Sudradjat, S. E. (2019). Study of the Effects of E-Cigarettes on Health. Journal of Clinical Medicine, 25(3), 115–117. https://doi.org/10.36452/jkdoktmeditek.v25i3.1775 DOI: https://doi.org/10.36452/jkdoktmeditek.v25i3.1775

Sugiyono. (2019). Quantitative, Qualitative, and R&D Research Methods. Alphabet.

Tsuboi, Y. (2025). AHRR DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices. Cancer Epidemiology Biomarkers Prevention A Publication of the American Association for Cancer Research Cosponsored by the American Society of Preventive Oncology, 34(10), 1836-1843, ISSN 1538-7755, https://doi.org/10.1158/1055-9965.EPI-25-0625 DOI: https://doi.org/10.1158/1055-9965.EPI-25-0625

Tualeka, A.R. (2025). Effects of supplementation rich in CYP2E1 and decarboxylase enzymes on leukocytes of smoking workers exposed to benzene at Osowilangon shoe industry home in Surabaya. Functional Food Science, 5(8), 393-401, ISSN 2767-3146, https://doi.org/10.31989/ffs.v5i8.1633 DOI: https://doi.org/10.31989/ffs.v5i8.1633

Waleleng, M. M., Rotty, L. W., & Polii, E. (2018). Comparison of Hemoglobin Levels of E-cigarette Users and Conventional Cigarettes in Adult Men in Manado. ECliniC, 6. DOI: https://doi.org/10.35790/ecl.6.2.2018.22118

Yanik, S.D. (2025). Cytokine production of mononuclear leukocytes in response to respiratory syncytial virus is increased in COPD but suppressed in non-COPD tobacco smokers. Molecular Medicine, 31(1), ISSN 1076-1551, https://doi.org/10.1186/s10020-025-01277-4 DOI: https://doi.org/10.1186/s10020-025-01277-4

Yu, J. (2025). Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study. Eye Basingstoke, 39(11), 2176-2182, ISSN 0950-222X, https://doi.org/10.1038/s41433-025-03838-7 DOI: https://doi.org/10.1038/s41433-025-03838-7

Zhu, H. (2025). Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. American Journal of Clinical Nutrition, 122(1), 39-47, ISSN 0002-9165, https://doi.org/10.1016/j.ajcnut.2025.05.003 DOI: https://doi.org/10.1016/j.ajcnut.2025.05.003

Downloads

Published

2025-11-22

How to Cite

Barus, P., & Irma, F. (2025). Comparison of Total Leukocytes in Conventional Smokers and E-Smokers in Students of the Faculty of Medicine, University of Muhammadiyah North Sumatra. Health & Medical Sciences, 3(1), 10. https://doi.org/10.47134/phms.v3i1.527

Issue

Section

Articles

Similar Articles

You may also start an advanced similarity search for this article.